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Deshmukh, Abhishek D.
- Medicated Chewing Gum:Modern Approach to Mucosal Drug Delivery
Authors
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 4 (2012), Pagination: 150-159Abstract
In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. It offers various advantages over conventional drug delivery systems. Unlike chewable tablets medicated gums are not supposed to be swallowed and may be removed from the site of application without resorting to invasive means.
Over the years, patient convenience and patient compliance-oriented research in the field of drug delivery has resulted in bringing out potential innovative drug delivery options. Out of which, medicated chewing gum (MCG) offers a highly convenient patient-compliant way of dosing medications, not only for special population groups with swallowing difficulties such as children and the elderly, but also for the general population, including the young generation. Medicated chewing gum delivery system is convenient, easy to administer - anywhere, anytime - and is pleasantly tasting making it patient acceptable. It offers a wide range of advantages that make it an excellent alternative. It can be used to prevent or cure the dental caries, smoking cessation, pain, obesity, xerostoma, acidity, diabetes etc.
Keywords
Medicated Chewing Gum, Invasive, Xerostoma, Smoking Cessation.- Nanocochleate:A Review
Authors
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 3 (2012), Pagination: 153-159Abstract
The nanocochleate drug delivery vehicle is based upon encapsulating drugs in a multilayered, lipid crystal matrix (a cochleate) to potentially deliver the drug safely and effectively. Nanocochleates are cylindrical (cigar-like) microstructures that consist of a series of lipid bilayers. Nanocochleate delivery vehicles are stable phospholipid-cation precipitates composed of simple, naturally occurring materials, generally phosphatidylserine and calcium. They have a unique multilayered structure consisting of a solid, lipid bilayer sheet rolled up in a spiral or in stacked sheets, with little or no internal aqueous space. This structure provides protection from degradation for associated "encochleated" molecules negatively charged lipids and drugs or peptides acting as the inter‐bi‐layer bridges instead of multi‐cationic metal ions. This new type of cochleate opened up to form large liposomes when treated with cationic salt, suggesting that cationic organic molecules can be extracted from these cochleates in a way similar to multivalent metal ions from metal ion‐bridged cochleates. Cochleates can be produced in sub‐micron size using a method known as "hydrogel cochleation" or simply by increasing the ratio of multivalent cationic peptides over negatively charged liposomes. When nanometer‐sized cochleates and liposomes containing the same fluorescent labeled lipid component were incubated with human fibroblasts cells under identical conditions.Keywords
Cochleate, Bilayers, Phosphatidylserine, Encochleated, Peptides.- Liposome as a Drug Delivery System-A Review
Authors
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra 444602, IN
2 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra,444602, IN